Sepsis-associated encephalopathy
Conditions
Interventions
control group:N/A
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years; 2. Experimental group: According to the "Save Sepsis Movement: International Guidelines for the Treatment of Sepsis and Septic Shock 2021 Edition" jointly developed by the European Society of Critical Care Medicine (ESICM) and the American Society of Critical Care Medicine (SCCM), patients with sepsis and Patients with sepsis-related encephalopathy who need cerebrospinal fluid auxiliary examination to exclude intracranial infection; 3. Control group: patients diagnosed with sepsis and without sepsis-related encephalopathy.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Chronic liver and kidney failure; 3. Severe electrolyte imbalance; 4. After CPR; 5. Autoimmune diseases; 6. HIV infection; 7. Central nervous system infection; 8. Cerebrovascular accident; 9. Intracranial organic lesions; 10. The application of drugs to interfere with the observation of cognitive function; 11. The application of drugs has an biology effect on the immune system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single cell RNA-seq;RNA-seq; | — |
Secondary
| Measure | Time frame |
|---|---|
| cell morphology in cerebro-spinal fluid;S100ß/NSE/S100A8 in cerebrospinal fluid;peripheral blood biochemical indicators;cerebral cortex thickness and the density of grey matter and white matter;regional cerebral oxygen saturation;electroencephalogram waveform;sequential organ failure assessment;mortality in emergency department sepsis score;glasgow coma score;richmond agitation-sedation scale;the confusion assessment method for the intensive care unit;montreal cognitive assessment; | — |
Countries
China
Contacts
Public ContactYanna Si
Nanjing First Hospital
Outcome results
None listed