Hyperuricemia
Conditions
Interventions
control group:orally take inosine tablets for 500mg
hyperuricemia group:orally take inosine tablets for 500mg
Sponsors
Shanghai 10th People’s Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male, Han nationality, aged 18-70 years; 2.(eGFR) > 60 mL/min/1.73m2; 3. Voluntary informed consent and participation.
Exclusion criteria
Exclusion criteria: 1. Using drugs affecting uric acid metabolism, such as allopurinol, fibulinastat, benzbromarone, atorvastatin, losartan, amlodipine, fenofibrate, pyrazinamide, diuretics, glucocorticoids, immunosuppressants, aspirin, etc.; 2. With malignant tumor, immune system disease, blood disease, tuberculosis and other related concomitant diseases; 3. Patients with uncontrolled hypertension, systolic blood pressure >= 180 and/or diastolic blood pressure >= 110 mmhg; 4. With abnormal glucose metabolism: fasting blood glucose > 10 mmol/L, and/or glycosylated hemoglobin >= 9%; 5. With abnormal liver and kidney function: patients with severe liver dysfunction (ALT and AST >= 2.5unl), patients with acute or chronic renal failure (EGFR < 30 ml/min).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| uric acid;inosine; | — |
Secondary
| Measure | Time frame |
|---|---|
| creatine;total cholesterol;triglyceride;glucose;Alanine aminotransferase;Aspartate aminotransferase;height;weight; | — |
Countries
China
Contacts
Public ContactChen Haibing
Shanghai 10th People’s Hospital
Outcome results
None listed