lung cancer
Conditions
Interventions
HIFU combined group:HIFU
Sponsors
Xiangtan Cental Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Cytologically or pathologically verified not-small-cell lung cancer; 3. Patients with liver metastasis or recurrence after operation; 4. There is no gene mutation target for targeted therapy; 5. The ECOG score is 0-2; 6. At least two measurable tumors according to RECIST 1.1; 7. Asymptomatic or symptomatic brain metastases under control; 8. Laboratory indicators showed no HIFU or contraindications to immunotherapy and chemotherapy; 9. Informed consent was obtained; 10.Participants' agreement to use effective contraception during the beginning of the trial and 90 days post-dose;
Exclusion criteria
Exclusion criteria: 1. Mixed lung cancer including neuroendocrine tumors, sarcoma; 2. Other malignant tumors developed within 5 years; 3. Uncontrolled pleural or pericardial effusion; 4. There were severe interstitial pneumonia and severe diffusion dysfunction in the lungs. 5. In liver failure; 6. Patients with autoimmune diseases requiring long-term hormone therapy; 7. Acute cardiovascular and cerebrovascular diseases such as acute cerebral infarction and acute coronary syndrome within 1 month; 8. Patients who are pregnant or breastfeeding; 9. Life expectancy of 3 months or less;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR, Objective Remission Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS, Overall Survival;DCR, Disease Control Rate;safety of life;quality of life;PFS, Progression-Free Survival; | — |
Countries
China
Contacts
Public ContactMingyan Jiang
Xiangtan Central Hospital
Outcome results
None listed