heart failure with preserved ejection fraction and sarcopenia
Conditions
Interventions
Resistance training group:Basic intervention+Resistance training
Resistance training+whey protein group:Basic intervention + Resistance training + Whey protein supplementation
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years old; 2. Meet the diagnostic criteria of sarcopenia (2019 AWGS2 standard, myopenia can be diagnosed once meeting (1)+(2) or (1)+(3) or (1)+(2)+(3)) (1) Appendicular skeletal muscle mass (ASM): dual-energy X-ray absorptiometry (DXA) (male = 12s; 3. Meet the diagnostic criteria of HFpEF (2018 Chinese guidelines for the diagnosis and treatment of heart failure): (1) Typical symptoms and/or signs; (2) Left ventricular ejection fraction >= 50%; (3) Elevated natriuretic peptide levels (BNP >= 35pg/mL or NT-proBNP >= 125 pg/mL), and meet at least 1 of the following: 1) Left ventricular hypertrophy and/or Left atrial enlargement; 2) Diastolic function abnormality; (4) Exclude non-cardiac diseases that cause similar symptoms; (5) NYHA functional class I and II 3. Be able to understand and sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Aerobic exercise and resistance exercise cannot be carried out due to physical disability; 2. Daily activities cannot be carried out due to cardiopulmonary diseases; 3. Other clinical trial drugs were taken or in other medical device trial within 30 days before admission; 4. II or III degree heart block or sick sinus syndrome without permanent pacemaker implantation; need implantable device therapy for heart failure; 5. Uncontrolled hypertension or postural hypotension; 6. ACS was happened in 3 months before admission, Coronary revascularisation is planned; 7. Impaired renal function (estimated glomerular filtration rate < 60ml/min/1.73 m2); 8. Impaired hepatic function (serum transaminase level 2 times higher than the normal reference value); 9. Cancer or other systemic diseases with an expected survival of less than 12 months; 10. Allergies to milk proteins; 11. Unable to participate in this study after the clinical evaluation by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6min walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| handgrip strength;Short Physical Performance Battery;Appendicular skeletal muscle mass;LVEF;Natriuretic peptide;Minnesota Living with Heart Failure Questionnaire;Mini Nutritional Assessment-Short Form;Mini Nutritional Assessment-Short Form; | — |
Countries
China
Contacts
Public ContactZheng Xiaoyun
China-Japan Friendship Hospital
Outcome results
None listed