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Efficacy of regional citrate anticoagulation in different models of continuous renal replacement therapy: a prospective, open, single-center randomized controlled trial

Efficacy of regional citrate anticoagulation in different models of continuous renal replacement therapy: a prospective, open, single-center randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061065
Enrollment
Unknown
Registered
2022-06-15
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury requiring RCA-based CRRT therapy

Interventions

1:CVVH
2:CVVHDF
3:CVVHD

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients treated with CRRT for AKI (AKI diagnosis criteria are based on the 2012 KDIGO AKI Clinical Practice Guidelines), and CRRT criteria refer to RENAL study; 2. Treatment time is more than 24 hours.

Exclusion criteria

Exclusion criteria: 1. A history of sodium citrate allergy; 2. Receiving therapeutic anticoagulation within 3 days prior to and during CRRT; 3. Severe liver failure, lactic acid level > 4mmol/L; 4. At the same time, plasma exchange, blood adsorption and other blood purification treatment mode; 5. Pregnant women and pregnant patients.

Design outcomes

Primary

MeasureTime frame
Filter life;free calcium concentration before and after the filter;—

Secondary

MeasureTime frame
urea;creatinine;uric acid;bicarbonate ion concentration;pH;hemoglobin;platelet;—

Countries

China

Contacts

Public ContactZhang Ling

West China Hospital, Sichuan University

zhanglinglzy@163.com+86 18980601985

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026