chronic kidney disease with hyperuricemia
Conditions
Interventions
Pre-stage control treatment::Saline, intravenous * 5 days
Post-stage trial treatment:Post trial treatment: 5% sodium bicarbonate solution, 1meq/kg body weight, intravenous for 5 days
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, Han nationality and unlimited gender; ? Glomerular filtration rate (eGFR) 30-60 ml/min/1.73m2 or GFR >= 60ml/min/1.73m2, combined with proteinuria and renal imaging changes; ? Hyperuricemia with blood uric acid >= 420umol/L.
Exclusion criteria
Exclusion criteria: 1. eGFR<30ml/min/1.73m2; 2. Abnormal liver function, with alanine aminotransferase and/or aspartate aminotransferase reaching 2 times or more of the upper limit of normal value; 3. Patients with acute gout; 4. Patients with unstable angina pectoris, or cardiac insufficiency grade III-IV (NYHA grade), or cerebrovascular diseases such as active intracerebral hemorrhage or new cerebral infarction, or those who need long-term diuretic treatment for any reason; 5. Have serious heart, lung, central nervous system diseases or malignant tumors; 6. Pregnant, pregnant or lactating women; 7. Those who have participated in any drug trial within 3 months before enrollment; 8. Those who cannot sign the informed consent form and do not agree to regular follow-up; 9. Other researchers think it is not suitable to be selected for this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum creatinine;urine protein;Glomerular filtration rate;24-hour urine biochemistry;Renal B-ultrasound; | — |
Secondary
| Measure | Time frame |
|---|---|
| total CO2;urine pH;blood pH;ALT;AST;Blood electrolyte;blood pressure;Blood bicarbonate;Dual energy CT of kidney;serum uric acid;blood sugar;Blood Fat; | — |
Countries
China
Contacts
Public ContactBao Hui
Outcome results
None listed