Renal insufficiency
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients requiring routine hemodialysis (HD) due to renal insufficiency; 2. Aged 18-70 yeas; 3. Heparin or low molecular weight heparin should not be used for anticoagulation in patients with active bleeding in vivo or with high risk of bleeding (such as gastrointestinal bleeding, cerebral hemorrhage, or bleeding at the surgical site); 4. The hemoglobin level is 70-120g /L; 5. Platelet level (100-350) x 10^9/L; 6. Blood calcium level is 1.8 to 2.5mmol/L; 7. Vascular access for arteriovenous fistula or deep vein indwelling catheter; 8. Hemodynamic stability; 9. Clear consciousness; 10. Normal cognitive ability, high compliance and willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Have a history of sodium citrate allergy; 2. History of cirrhosis or obvious liver function damage; 3. Extensive muscle tissue injury or muscle tissue insufficiency; 4. Need to mask oxygen or oxygenation index < 300mmHg. 5. Hemophilia or other history of coagulation; 6. The presence of systemic serious infection; 7. Patients with mental disorders can not cooperate with the treatment; 8. Other clinicians think that the overall condition is serious or obvious fluctuations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodialyzer and tube coagulation events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas analysis;Routine blood;The biochemical indicators;Blood coagulation indexes;iCa2+ clearance; | — |
Countries
china