Efficacy of intraoperative intravenous esketamine as a component of multimodal analgesia after gynecologic laparotomy: a prospective, randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200061021

Enrollment

Unknown

Registered

2022-06-15

Start date

2022-06-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecologic laparotomy for benign disease

Interventions

study group:intraoperative intravenous esketamine

Control group:intravenous infusion of equal dose of saline

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Eligible subjects were patients aged 18 to 65 years; 2. American Society of Anesthesiologists (ASA) physical status I-III; 3. Female patients undergoing elective open gynecological surgery were screened for inclusion in the study.

Exclusion criteria

Exclusion criteria: 1. Significant cardiovascular, gastric ulcer, hepatic, or renal disease; 2. Preoperative treatment with opioids or corticosteroids; 3. Allergies or contraindications to any drug used in the study; 4. Pregnancy or breastfeeding, or refusal to participate in the study.

Design outcomes

Primary

Measure	Time frame
quality of recovery;	—

Secondary

Measure	Time frame
pain score;morphine use;	—

Countries

China

Contacts

Public ContactZhiyu Geng

Department of Anesthesiology, Peking University First Hospital, Beijing, China

gengzhiyu2013@163.com+86 10 83573218

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026