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Clinical application of ultra-small stable calcium phosphate nanoclusters for the repair of demineralized enamel and dentin in human oral environment

Clinical application of ultra-small stable calcium phosphate nanoclusters for the repair of demineralized enamel and dentin in human oral environment

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200061012
Enrollment
Unknown
Registered
2022-06-15
Start date
2022-07-26
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental hard tissue disease

Interventions

1:Treatment of test material, positive control and blank control in sequence
2:Treatment of test material, blank control and positive control in sequence
3:Treatment of positive control, test material and blank control was conducted in sequence
4:Treatment of positive control, blank control and test material in sequence
5:Treatment of blank control, positive control and test material was conducted in sequence
6:Treatment of blank control, test material and positive control was conducted in sequence

Sponsors

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
23 Years to 26 Years

Inclusion criteria

Inclusion criteria: 1. Voluntary, able to attend the trial as scheduled and complete all procedures. 2. Adults in good overall health. 3. Oral health: no dental diseases such as caries or pulpitis, no periodontal diseases such as gingivitis or periodontitis, no oral mucosal diseases normal salivary gland function and have at least 28 natural teeth (not including wisdom teeth). 4. Must sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Presence of severe diseases (as judged by the clinical examiner), including but not limited to arrhythmia, uncontrolled hypertension, diabetes, hepatitis of various causes, renal failure, etc. 2. Any mental illness or other conditions that may legally restrict capacity for civil conduct. 3. Lack of civil capacity, or refuse to participate in the trial. 4. Using of medications that may alter the oral microbiome (e.g., antibiotics or inhibit saliva flow (e.g., antidepressants, antihistamines). 5. Orthodontic patients with fixed or invisible braces, or those wearing nightguards for bruxism. 6. Determined by the physician to be unsuitable for inclusion.

Design outcomes

Primary

MeasureTime frame
Microhardness;

Secondary

MeasureTime frame
Morphology;

Countries

China

Contacts

Public ContactXi Chen

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine

371921358@qq.com+86 180 1979 0296

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026