Effects of dexmedetomidine as adjuvant in superior laryngeal nerve block on hemodynamics and postoperative sore throat in patients with double lumen endotracheal intubation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200061001

Enrollment

Unknown

Registered

2022-06-15

Start date

2022-06-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer

Interventions

Control Group:None

Superior laryngeal nerve block Group:Superior laryngeal nerve block

Adjuvant Group:Dexmedetomidine as adjuvant in superior laryngeal nerve block

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA grade I-III; 2. Age >= 18 years old; 3. Body mass index 18-35; 4. All patients underwent thoracoscopic lobectomy with one lung ventilation under general anesthesia; 5. All operations were performed under general anesthesia or combined with superior laryngeal nerve block; 6. All anesthesia and surgical management are carried out by the same team; 7. The patient signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Contraindications to general anesthesia; 2. Serious heart, liver or kidney disease; 3. History of mental disorders or excessive use of opioid analgesics; 4. Taking drugs that affect blood pressure and heart rate for a long time; 5. Electrolyte disorder; 6. Patients predicted to have a difficult airway; 7. History of surgery or anesthesia within 6 months; 8. Contradictions or complications of superior laryngeal nerve block, including coagulation dysfunction, local infection and local anesthetic toxicity; 9. Conversion to thoracotomy; 10. Patients with long-term poor blood glucose control or complicated with diabetes before operation; 11. Patients with metabolic disorders associated with increased or decreased cortisol; 12. Patients with severe cognitive impairment or language problems; 13. Patients who did not sign informed consent.

Design outcomes

Primary

Measure	Time frame
Sore throat 6 hours after operation;Restlessness score at eye opening;	—

Secondary

Measure	Time frame
Sore throat after operation;heart rate;MAP;SpO2;RPP;Intubation time;Operation time;Cough score when opening eyes;	—

Countries

China

Contacts

Public ContactZhao Xin

The Second Hospital of Shandong University

lujnzx@sohu.com17860085551

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026