Helicobacter pylori infection
Conditions
Interventions
PPI bismuth quadruple Group:Esomeprazole 20mg bid + bismuth potassium citrate 220mg bid + amoxicillin 1g bid + clarithromycin 0.5g bid for 14 days
Vonorazan Triple 1 Group:Vonolazan 20mg bid + amoxicillin 1g bid + clarithromycin 0.5g bid for 14 days
Vonorazan Triple 2 Group:Vonolazan 20mg bid + amoxicillin 1g bid + clarithromycin 0.5g bid for 10 days
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 65 years, male or female; 2.The presence of Hp infection is proved by any one of a C13 or C14 breath test, rapid urease test, or histopathology; 3.Have not received Hp eradication treatment before, that is, the initial treatment; 4.No allergy to penicillin or previous use of amoxicillin; 5.No history of allergy to the drugs in the research protocol; 6.Signed to agree to participate in this study voluntarily, actively cooperate with the follow-up and bear the relevant medical expenses.
Exclusion criteria
Exclusion criteria: 1.Patients with active gastrointestinal bleeding; 2.History of upper gastrointestinal surgery; 3.Pregnant, lactating women and those who are unwilling to take contraceptive measures during the trial; 4.The patient also has other serious diseases that affect the evaluation of this study, such as severe liver disease, lung disease, heart disease, kidney disease, malignant tumor and alcoholism; 5.Patients who cannot express their main complaints correctly, such as mental illness or severe neurosis, cannot cooperate with this trial; 6.Allergy history to the test drug; 7.There are factors considered by other researchers that may affect the accuracy of the test results and the interests of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hp eradication success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient compliance;The incidence of adverse reactions;Safety; | — |
Countries
China
Contacts
Public ContactZibin Tian
The Affiliated Hospital of Qingdao University
Outcome results
None listed