Nasal endoscopic surgery
Conditions
Interventions
Esketamine group:The patients received 0.25mg/kg esketamine completed within 10 minutes before the induction of anesthesia followed by continuous infusions of 0.25mg/kg/hr esketamine
Lidocaine group:The patients received 2mg/kg lidocaine completed within 10 minutes before the induction of anesthesia followed by continuous infusions of 2mg/kg/hr lidocaine
Saline control group:The patients received the same volume of 0.9% normal saline intravenoudly during anesthesia
Sponsors
The Affiliated Huaian Hospital of Xuzhou Medical University.Huai'an Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ASA I-II patients aged 18-65 years undergoing nasal endoscopic surgery under general anesthsia(including endoscopic sinus open surgery,endoscopic radiofrequency ablation of turbinate,endoscopic correction of nasal septum deviation )
Exclusion criteria
Exclusion criteria: ?Not signing informed consent;?Allergic to esketamine or local anesthetics; ?Patients with poor understanding ability,mental disorder or central nervous system disorder could not cooperate before surgery;?Patients with serious liver,kidney,heart and lung diseases;?Long-term use of painkillers or medications;?Chronic alcoholics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Quality of Recovery-40 (QoR-40) survey;Self-Rating Anxiety Scale;Self-Rating Depression Scale; | — |
Countries
China
Contacts
Public ContactChenglan Xie
Outcome results
None listed