HBV
Conditions
Interventions
Test Group:Take TAF orally
matched group:Take TDF orally
Sponsors
Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Hepatitis B surface antigen positive, and HEPATITIS B VIRUS DNA positive, but no liver cirrhosis, liver cancer, no HEPATITIS B virus carriers with elevated ALT; 2) 18-75 years old; 3) Understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) With other types of hepatitis virus or HIV infection; 2) Participated in other clinical trials in recent 1 month; 3) Women who are pregnant or breastfeeding; 4) Simultaneous use of other antiviral drugs; 5) History of schistosomiasis cirrhosis; 6) intrahepatic cholangiolithiasis with cholangitis; 7) Patients with severe fatty liver; 8) Patients with various autoimmune liver diseases; 9) Allergic history of TAF, TDF and its components; 10) acute and chronic renal insufficiency;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver stiffness; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;hepatorenal function;Liver fibrosis index 5;HBV DNA;Liver CT/MR; | — |
Countries
China
Contacts
Public ContactXu Xiao
Outcome results
None listed