anxiety
Conditions
Interventions
E group:0.3mg/kg esketamine prior surgery
C group:equal volume of normal saline
Sponsors
Xiangyang center hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.age 18-65 years female; 2.plan to receive breast and thyroid surgery; 3.ASA:?-?; 4.consent to participate the clinical trial.
Exclusion criteria
Exclusion criteria: 1. Expected hospital stay < 72h; 2. Patients who are expected to enter the ICU after surgery; 3. Patients who are expected to return to the ward with a tracheal tube after surgery; 4. Any patient who is allergic to esketamine or excipients; 5. Patients with severe disturbance of consciousness or mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.) and cognitive dysfunction; 6. A history of severe cardiovascular disease (congestive heart failure, severe angina pectoris, or unstable angina or myocardial infarction within 6 months); 7. Pregnant or lactating patients; 8. Patients with MMSE score <18; 9. Patients with any of the following contraindications to the use of esketamine injection: 1. Patients with serious risk of elevated blood pressure or intracranial pressure; 2. Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; 3. Poor control Patients with untreated or untreated hypertension (arterial hypertension, resting systolic blood pressure over 180 mmHg, or resting diastolic blood pressure over 100 mmHg); 10. Untreated or insufficiently treated patients with hyperthyroidism (hyperthyroidism).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anxiety;pain;pain; | — |
Countries
Chian
Contacts
Public ContactGong Xingrui
Xiangyang center hospital
Outcome results
None listed