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Feasibility study of adjuvant benign and malignant diagnosis of pulmonary nodules based on ctDNA methylation characteristics, mutation characteristics and T cell receptor (TCR) characteristics

Feasibility study of adjuvant benign and malignant diagnosis of pulmonary nodules based on ctDNA methylation characteristics, mutation characteristics and T cell receptor (TCR) characteristics

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060902
Enrollment
Unknown
Registered
2022-06-14
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary nodule

Interventions

Benign group:surgery
Benign group:sequencing
Malignant group:surgery
Malignant group:sequencing
Benign group:draw blood
Malignant group:draw blood

Sponsors

The second hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Aged between 18 and 75; 2.CT scan revealed a single pulmonary nodule; 3.The diameter of pulmonary nodules is between 5mm and 30mm; 4.Planned to undergo resection for pulmonary nodules; 5.There is no evidence of lymphatic or distant metastasis; 6.Agree to sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating women; 2.The diameter of pulmonary nodules is greater than 30mm; 3.One patient had 2 or more pulmonary nodules; 4.Patients who were not pathologically confirmed after surgery or patients with cancer pathologically confirmed within 2 years before enrollment; 5.Any signs of lymphatic or distant metastasis; 6.Any other disease or condition of clinical significance that the investigator considers may affect protocol compliance,or affect patients' signing of informed consent (ICF), or make them unsuitable for the study.

Design outcomes

Primary

MeasureTime frame
ctDNA methylation characteristics;ctDNA mutation characteristics;T cell receptor (TCR) characteristics;

Countries

China

Contacts

Public ContactXuefei Zhang

The second hospital of Dalian Medical University

17709872528@163.com+86 17709872528

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026