hematological malignancies
Conditions
Interventions
experimental group:EAP regimen
Sponsors
The Affiliated People's Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Based on the Gruppo italiano Trapianto di Midollo Osseo working group, hematological malignancy patients that are determined as Proven poor mobilizersor Predicted poor mobilizerswill be included. 2.There are indicators proving the patient can undergo Auto-HSCT. 3.ECOG rating of 0~2. 4.Age between 18 and 75. 5.More than 3 months of expected survival time. 6.Have signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Having severe cardiac, hepatic or renal insufficiency: II or above severe arrhythmia; bilirubin, alanine aminotransferase, and aspartate aminotransferase that are 2 times higher than the upper limit of normal threshold in serum; an endogenous creatinine clearance of <50% in serum; 2.Active infection; 3.Allergy to VP-16, Ara-C and PEG-rhG-CSF; 4.Pregnant or lactating woman; 5.Received live or live attenuated vaccines within four weeks before enrollment; 6.deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with target collection values for the EAP mobilization regimen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with ideal collection values for the EAP mobilization regimen;average number of collection;time of PEG-rhG-CSF mobilization until collection;toxic side effects of EAP regimen;independent variables that cause EAP mobilization failure; | — |
Countries
China
Contacts
Public ContactPeipei Ye
The Affiliated People's Hospital of Ningbo University
Outcome results
None listed