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The median effective dose(ED50) of intravenous oxycodone combined with different induction doses sufentanil for postoperative analgesia following thoracic surgical procedures in elderly

The median effective dose(ED50) of intravenous oxycodone combined with different induction doses sufentanil for postoperative analgesia following thoracic surgical procedures in elderly

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060850
Enrollment
Unknown
Registered
2022-06-12
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

1:0.3µg/kg Sufentanil
2:0.5µg/kg Sufentanil

Sponsors

Longbo
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective radical lung cancer surgery in our hospital from February 2022 to January 2023 were selected 2.Inclusion criteria: American Society of Anesthesiologists (ASA) rating ? - ?;Aged >=65 years old; Body Mass Index (BMI) : 18-22kg/?

Exclusion criteria

Exclusion criteria: 1.preoperative history of chronic pain; 2.Contraindicated users of opioids or psychotropic drugs; 3.History of mental illness or inability to work together; 4.Patients with cognitive dysfunction before surgery; 5.Refused to participate in the experimenter; 6.Patients with operation time > 3 hours; 7.The number of poke cards used in thoracoscopic surgery was > 3; 8.She had a history of motion sickness and took analgesic and antiemetic drugs 24 hours before surgery.

Design outcomes

Primary

MeasureTime frame
NRS score;

Secondary

MeasureTime frame
RASS score;Nu-DESC score;Respiratory depression, nausea and vomiting, delirium, chills, delayed wake up, dizziness, pruritus, postoperative agitation;

Countries

China

Contacts

Public ContactLongbo

Shengjing Hospital of China Medical University

longbo_27@163.com+86 18940259927

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026