HBV
Conditions
Interventions
1:TAF
2:TDF
Sponsors
The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients with chronic hepatitis B who are first found positive for hepatitis B surface antigen and need antiviral therapy according to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2019 edition) (Figure 1); Or chronic hepatitis B treated with other nucleotide antiviral drugs, but the reexamination of HBV DNA is still positive; 2.18-75 years old; 3.Understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1.With other types of hepatitis virus or HIV infection; 2.Patients who have participated in other clinical trials in the last 1 month; 3.Women who are pregnant or breastfeeding; 4.Simultaneous use of other antiviral drugs; 5.History of schistosomiasis cirrhosis; 6.intrahepatic cholangiolithiasis with cholangitis; 7.Patients with severe fatty liver; 8.Patients with various autoimmune liver diseases; 9.Patients currently receiving antiviral therapy with interferon -a. 10.Allergic history of TAF, TDF and its components; 11.Acute and chronic renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver hardness test;LN;HA;PCIII;Blood routine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions and safety;hepatic and renal function;HBV DNA;blood clotting function;bone mineral density; | — |
Countries
China
Contacts
Public ContactXu Xiao
The Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed