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Hydrogen inhibits the stress response of TF-MMP9-activated fiber reduction branchoscopy by upregulating AMPK-SCO3

Hydrogen inhibits the stress response of TF-MMP9-activated fiber reduction branchoscopy by upregulating AMPK-SCO3

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060838
Enrollment
Unknown
Registered
2022-06-12
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases that require fibromycytosis

Interventions

Sponsors

Nanjing Jiangning Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.18 years old<= age <= 80 years old, gender is not limited; 2.Patients who intend to undergo bronchoscopic diagnosis and treatment; 3.ASA rating is I to III; 4.18 kg/m 2 <BMI<30 kg/m2 5.Clearly understand and voluntarily participate in the study, and sign an informed consent form by the person himself.

Exclusion criteria

Exclusion criteria: 1.There are contraindications to bronchoscopic operation, such as severe superior vena cava obstruction syndrome; 2.Have severe respiratory lesions (obstructive sleep apnea syndrome, acute respiratory infection, chronic obstruction 3.Acute onset of lung disease, uncontrolled asthma, active haemoptysis, severe pulmonary hypertension, etc.); 4.Emergency surgery; hypovolemia, shock or coma; 5.Acute heart failure; unstable angina; myocardial infarction within 6 months before screening; third-degree atrioventricular transmission 6.Conduction block; severe arrhythmias; 7.Severe abnormalities in blood coagulation and liver and kidney function; 8.Suffering from mental system diseases; 9.Pregnant and lactating women; 10.The investigator deems it inappropriate to participate in the clinical trial

Design outcomes

Primary

MeasureTime frame
Check the number of coughs within 20 minutes of the start;

Secondary

MeasureTime frame
Inflammatory cell count of bronchoalveolar lavage fluid;heart rate;mean arterial pressure;blood oxygen saturation;Intraoperative anesthesia dosage;Incidence of adverse reactions;

Countries

China

Contacts

Public ContactLong Yun
a162033973@163.com+86 13512516996

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026