vaginitis
Conditions
Interventions
Placebo group:Placebo
Lactobacillus crispatus group:500 million Lactobacillus crispatus 197
Lactobacillus gasseri group:500 million Lactobacillus gasseri CCFM1201
Compound probiotic group:Lactobacillus crispatus 197 and Lactobacillus gasseri 1201 total 500 million
Compound Probiotics and Prebiotics:Fructo oligosaccharides, Lactobacillus crispatus 197 and Lactobacillus gasseri CCFM1201 (500 million in total)
Sponsors
The Peoples' hospital of Xishan district of Wuxi city
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.The patient was in line with bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC)diagnostic criteria; 2.Women aged 18-65, pre-menopausal and with a history of sexual activity; 3.Good compliance, able to comply with the requirements of clinical trials; 4.The subject or guardian has signed the informed consent and promised to cooperate with the study throughout the study period.
Exclusion criteria
Exclusion criteria: 1.Current or past 3 weeks of vulvar infection, urinary tract infection, sexually transmitted infection (gonorrhea, Trichomoniasis, genital herpes, syphilis, HIV), pelvic inflammatory disease; 2.Pregnant women, pregnant women and lactating women; 3.Allergic constitution such as drug allergy and lactose intolerance; 4.Long-term use of contraceptives and immunosuppressants; 5.Patients with systemic diseases (such as albinism, leukemia, malignant tumor history); 6.Antibiotics, antifungals, topical steroids, or antivirals were taken orally or were being taken orally within 3 months prior to visit (oral or topical); 7.A history of mental illness; 8.Those who had used estrogen or estrogens within 6 months prior to the study; 9.Patients with a history of urogenital surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal flora;Blood routine;Vaginal flora;Serum IgA;Serum IgG;Leucorrhea routine;Fecal flora genomics;Vaginal flora genomics;Vaginal secretion metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight;Urine routine; | — |
Countries
China
Contacts
Public ContactQiuxiang Zhang
Outcome results
None listed