Memory CD8+ T cell regulates the immune disorder of sepsis

Immune checkpoints Siglec-9/E regulates the immune disorder of sepsis through memory CD8+ T cell

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200060826

Enrollment

Unknown

Registered

2022-06-12

Start date

2022-06-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

4:No

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: During the study period, all emergency department patients at the site were defined as Sepsis-3.0 (Singer M, et.al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016 Feb 23; 315(8): 801-10.) As a diagnostic criterion, age >= 18 years, male or female;Sign an informed consent form.

Exclusion criteria

Exclusion criteria: Pregnant or lactating women; serious primary diseases affecting survival (such as unresectable tumors, blood diseases, cerebrovascular diseases leading to prolonged bed rest, Alzheimer's disease, HIV, etc.); immunosuppressants used in the past 6 months; psychotic patients; participants who have participated in other clinical trials within 30 days; investigators judge that they cannot complete or are not suitable for this trial.

Design outcomes

Primary

Measure	Time frame
28d mortality;Serum cytokines;mononuclear subgroup;	—

Countries

China

Contacts

Public ContactYan-Cun Liu

Tianjin Medical University General Hospital

yancunliu@tmu.edu.cn13920762773

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026