stroke
Conditions
Interventions
Low frequency group:rTMS treatment with stimulation intensity of 120% rMT and frequency of 1Hz, acting on the motor cortex of the contralateral side, stimulation for 5 seconds, rest for 45 seconds, re
High frequency group:rTMS treatment with stimulation intensity of 120% RMT and frequency of 10 Hz, acting on the motor cortex of the affected side, continuous stimulation for 20 minutes, a total of 12
coupling group:First intervene in low-frequency stimulation for 2 weeks, and then intervene in high-frequency stimulation for 2 weeks. The stimulation program is the same as above, once/day, 5 times/w
Sponsors
Huashan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Stroke hemiplegia subjects inclusion criteria: 1.Aged 18-75 years old; 2.Meet the diagnostic criteria of stroke, and confirmed by CT or MRI as unilateral subcortical infarction or hemorrhage; 3.Patients with first onset or past onset without sequelae; 4.For patients in subacute stage, 3 months = grade II on the affected side; 6.The vital signs are stable; 7.Those who voluntarily participate in the research and can cooperate with the measurement; 8.Understand and sign the informed consent. Inclusion criteria for healthy subjects: 1.Age, gender and post-stroke hemiplegia subjects are matched, and the age difference can be ±5 years; 2.The vital signs are stable; 3.There is no upper limb dysfunction; 4.No history of abnormal medical history such as related head trauma, drug abuse and neuropsychiatric diseases; 5.Those who voluntarily participate in the research and can cooperate with the measurement; 6.Understand and sign the informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for hemiplegic subjects with stroke 1.Those with severe cognitive impairment and mental illness who cannot cooperate with the assessment; 2.Patients with a history of epilepsy; 3.Implanted cardiac pacemaker or intracranial metal implant; 4.Severe medical diseases (such as heart failure and renal failure with advanced malignant tumor) and patients with unstable clinical symptoms; 5.Those with obvious damage to the upper limbs currently affected by stroke, such as fixed contracture, frozen shoulder, severe arthritis, and recent fractures; 6.Pregnant women. Healthy Subject Exclusion Criteria 1.Patients with a history of epilepsy; 2.Those who have implanted cardiac pacemakers or metal implants in the brain; 3.Those with obvious damage to the upper limbs, such as fixed contracture, frozen shoulder, severe arthritis, and recent fractures; 4.There are underlying diseases such as hypertension, diabetes, hyperlipidemia, coronary heart disease, etc; 5.Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical scales: Fugl-Meyer rating scale for upper extremity (FMA-UE), Brunnstrom grading scale, Action Research Arm Test (ARAT), nine-hole test, muscle strength, range of motion, brief mental state Examination Scale (MMSE), Modified Ashworth Score, Modified Barthel Index;TMS assessment: resting motor threshold, motor evoked potential, central motor conduction time, Interhemispheric Inhibition.;Surface EMG: including the root mean square of the maximal isometric EMG signals of the biceps, triceps, extensors, and flexor carpi radialis;Near-infrared functional brain imaging; | — |
Countries
China
Contacts
Public ContactJIAN HU
Huashan Hospital affiliated to Fudan University
Outcome results
None listed