Effect of rScO2-oriented hemodynamic management in elderly patients after major noncardiac surgery
Conditions
Interventions
Intervention group:With an rScO2-oriented hemodynamic management strategy, the target is to maintain rScO2 =90% of the baseline value and MAP =65 mmHg or within ± 20% of the baseline value using vasop
Control group:Through invasive hemodynamic monitoring, the target is to maintain MAP =65 mmHg or within ± 20% of the baseline value using vasopressors.
Sponsors
Department of Anesthesiology, The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients aged 60-90 years; 2.Major noncardiac surgery planned under general anesthesia; 3.ASA classification II or III; 4.An estimated surgical duration of 2 hours or more.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Spinal and/or epidural anesthesia; 3. Severe untreated or uncontrolled hypertension with systolic blood pressure (SBP) >= 180 mm Hg or diastolic blood pressure (DBP) >= 110 mm Hg despite medication; 4. Preoperative acute cardiovascular events, including acute or decompensated heart failure and acute coronary syndrome; 5. Acute phase of cerebrovascular disease or cerebrovascular accident; 6. Liver insufficiency (Child-Pugh grade >= B); 7. Chronic kidney disease with creatinine >= 200µmol/L or end-stage renal disease requiring renal replacement therapy; 8. Preoperative sepsis; 9. Refuse to participate.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Mortality and incidence of complications within 30 days after surgery; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of major complications within the first 7 days after surgery; | — |
Countries
China
Contacts
Public ContactFuhai JI
The First Affiliated Hospital of Soochow University
Outcome results
None listed