esophageal cancer
Conditions
Interventions
A:S-1
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1.Pathologically confirmed elderly patients with esophageal cancer >= 65 years old, including squamous carcinoma and adenocarcinoma; 2.Newly treated patients who are inoperable or refuse surgery; 3.KPS > 70, body surface area > 1.5m2, can eat more than semi-liquid diet; 4.Stage IB-IVA patients with AJCC stage 8; 5.Expected survival > 1 year; 6.Routine hematuria and liver, kidney, cardiopulmonary function showed no contraindations of radiotherapy and chemotherapy (WBC >= 3.5 x 10^9/ L, NE >= 1.5 x 10^9/ L, PLT >= 100 x 10^9/ L, Hb >= 100g/ L, ALT/AST <= 2.0 times the upper limit of normal value; 7.No history of serious hypertension or cardiovascular and cerebrovascular accidents; 8.Synchronous chemotherapy regimen was ticio and capecitabine.
Exclusion criteria
Exclusion criteria: 1.Neoadjuvant chemotherapy or other systemic therapy, such as targeted therapy, immunotherapy; 2.complicated with other malignant tumors; 3.severe heart, lung, liver and kidney function injury; A history of severe allergies; 4.Interstitial pneumonia or other infections affect the efficacy of radiotherapy and chemotherapy; 5.Stage IVb patients with distant metastasis; 6.tracheoesophageal fistula, esophageal perforation or possible invasion of the aorta; 7.People who cannot eat or have bad fluid quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate (ORR);Overall survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival (PFS); | — |
Countries
China
Contacts
Public ContactChangxiaojing
The Second Hospital of Hebei Medical University
Outcome results
None listed