Cognitive dysfunction
Conditions
Interventions
Group D:Dexmedetomidine sedation
Group R:Remazolam sedation
Sponsors
Qujing First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
70 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who intend to undergo elective hip surgery; 2. Proposed lumbar hard combination anesthesia or other spinal canal anesthesia; 3. Aged >= 70 years, regardless of sex; 4. ASA grade I-III, NYHA grade I-III; 5. Preoperative MMSE score below normal (overall score of 30 points, normal cut-off criteria are: illiterate > 17 points, primary school > 20 points, junior high school and above > 24 points) or have one of the following high risk factors for dementia: subjective memory loss stated by the patient or his family, family history of dementia, educational attainment is illiterate or primary school, renal insufficiency, frail scale score of >= 3 or BMI <= 17.
Exclusion criteria
Exclusion criteria: 1. There are contraindications to spinal anesthesia: lumbar deformity, lumbar disc herniation, lumbar fracture, lumbar fracture after internal fixation, central nervous system infection, coagulation dysfunction (PT prolonged for more than 3 seconds, APTT prolonged for more than 10 seconds), platelet 180 mmHg and/or DBP > 110 mmHg, fasting blood glucose > 10 mmol/L, severe organ dysfunction; 8. Postoperative ICU need to be sent to continue treatment; 9. Intraspinal puncture is unsuccessful or general anesthesia due to surgical needs; 10. Other conditions that investigators judge are not suitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mini-mental state examiniation; | — |
Secondary
| Measure | Time frame |
|---|---|
| interleukin-6; | — |
Countries
China
Contacts
Public ContactYixuan Ouyang
Qujing First People's Hospital of Yunnan Province
Outcome results
None listed