sepsis
Conditions
Interventions
Group 1:Alpha lipoic acid 1200 mg/day * 7days
Group 2:saline 100 mL/day * 7days
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with sepsis according to the Guidelines for Emergency Treatment of Sepsis/Septic Shock in China 2018 and hs-cTnT more than normal, NT-proBNP > 450 ng/L (18-49 years) or > 900 ng/L (50-74 years) or > 1200 ng/L (GFR < 60 mL/min); 2. Aged 18-75 years; 3. Sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. More than 72 hours after meeting the inclusion criteria; 2. Patients with previous heart disease, such as myocardial infarction, coronary heart disease, congenital heart disease, cardiomyopathy, valvular disease, cardiothoracic surgery, after CRP or electrical cardioversion; 3. There are other life-threatening diseases such as cancer, renal failure (previously dependent on dialysis), severe chronic liver damage (Child-Pugh C); 4. Expected survival time < 24 hours; 5. Known or estimated limited treatment decisions (eg. no attempt at resuscitation or mechanical ventilation/dialysis); 6. Patients who are participating in other clinical trials; 7. Pregnant or breastfeeding women; 8. Patients who are allergic to ALA or similar drugs (B vitamins), and intolerant to the recommended dosage of ALA in the past; 9. Patients use immunosuppressive drugs or treated with chemoradiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause death;ICU admission;all-cause death in 3 month; | — |
Countries
China
Contacts
Public ContactChenling Yao
Zhongshan Hospital, Fudan University
Outcome results
None listed