non ST-segment elevation acute coronary syndrome
Conditions
Interventions
Group A:Subcutaneous injection of fondaparinux sodium
Group B:Subcutaneous injection of low molecular weight heparin sodium
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Patients diagnosed with ACS but not suitable for PCI or failed to attempt PCI and received simple coronary artery bypass grafting (CABG); The specific definition criteria were: coronary angiography showed that the left main artery stenosis was greater than or equal to 50% and / or three coronary artery lesions were greater than or equal to 70%, the lesions were seriously calcified, tortuous and angular, the emergency PCI treatment failed, or the complete revascularization could not be achieved, which was not suitable for PCI; 3. Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Emergency thrombolytic therapy; 2. Simultaneous CABG and valve replacement / plastic surgery, abnormal structure repair or correction, atrial fibrillation maze surgery (COX) and so on; 3. Patients who stopped fondaparinux sodium or low molecular weight heparin for more than 24 hours before operation; 4. Patients treated with fondaparinux sodium and low molecular weight heparin within 24 hours before operation; 5. Fondaparinux sodium / low molecular weight heparin and platelet glycoprotein IIb / IIIa receptor antagonist were used simultaneously before operation; 6. Body weight < 40 kg; 7. Creatinine clearance rate <= 20 mL/min; 8. Active bleeding with clinical significance before using fondaparinux sodium or low molecular weight heparin; 9. Acute bacterial endocarditis; 10. Acute myocarditis; 11. CABG is non-stop operation; 12. The perfusion mode of systemic circulation is retrograde perfusion (through femoral artery).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| major cardiovascular events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Composite endpoints of major cardiovascular events, heart failure, cardiogenic shock, sustained ventricular arrhythmia, or death from any cause; | — |
Countries
China
Contacts
Public ContactYuyang Chen
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed