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Preliminary study on the effect of VHL protein expression in advanced / metastatic clear cell renal carcinoma on the prognosis of nephrectomy

Preliminary study on the effect of VHL protein expression in advanced / metastatic clear cell renal carcinoma on the prognosis of nephrectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060706
Enrollment
Unknown
Registered
2022-06-08
Start date
2022-05-30
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

renal clear cell carcinoma

Interventions

case series:NA

Sponsors

Zhongnan Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Renal clear cell carcinoma diagnosed by pathology; 2. It is considered as advanced / metastatic clear cell renal carcinoma by PET-CT, CT or MRI: T4N0~1M0/T1~4N0~1M1; 3. Surgical tumor reduction treatment; 4. ECOG score <= 2; 5. Renal cell carcinoma tissues can be obtained for immunohistochemical staining of VHL protein and CAIX protein.

Exclusion criteria

Exclusion criteria: 1. Patients whose life expectancy is less than 1 year at the time of diagnosis of renal cell carcinoma; 2. Patients with other tumor diseases; 3. Renal cell carcinoma with other pathological types except renal clear cell carcinoma; 4. Patients with severe liver function impairment (Child Pugh grade C) when diagnosing renal cell carcinoma; 5. Patients with severe renal function impairment requiring long-term dialysis treatment when diagnosing renal cancer; 6. Patients with severe myelosuppression and severe neutropenia at the time of diagnosis of renal cancer.

Design outcomes

Primary

MeasureTime frame
Overall survival;

Countries

China

Contacts

Public ContactHua Xu

Zhongnan Hospital of Wuhan University

xuhuawhu@163.com+86 13971051016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026