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Preoperative GnRH agonist Alleviate Acute Postoperative Pain after Total Laparoscopic Hysterectomy for Adenomyosis

Preoperative GnRH agonist Alleviate Acute Postoperative Pain after Total Laparoscopic Hysterectomy for Adenomyosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060698
Enrollment
Unknown
Registered
2022-06-08
Start date
2022-06-01
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

adenomyosis

Interventions

uterine fibroid :no
adenomyosis-a group:no
adenomyosis-b group:preoperative goserelin

Sponsors

Zhejiang Provincial People‘s Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 55 Years

Inclusion criteria

Inclusion criteria: The details of inclusion criteria were as follows: adenomyosis or uterine fibroid as the indication for hysterectomy diagnosed through preoperative ultrasound, age 25–55 years and American Society of Anesthesiologists (ASA) physical status classification of I to II. The diagnostic criteria for adenomyosis included a myometrial lesion, a distorted and heterogeneous myometrial echotexture, and a globular and/or asymmetric uterus. All patients with symptoms of adenomyosis, such as dysmenorrhea, menorrhagia, or menostaxis, were recruited in this study. One cycle of subcutaneous injections of goserelin (Zoladex 3.6 mg, AstraZeneca, UK) as pretreatment were performed for some patients before laparoscopic hysterectomy of adenomyosis. The diagnostic criteria for uterine fibroids included a markedly enlarged uterus containing fibroid diagnosed by ultrasonography and with symptoms such as menorrhagia, frequent urination or other relative symptom.

Exclusion criteria

Exclusion criteria: The exclusion criteria were as follows: cancer, infection, smoking history, body mass index of >35 kg/m2, alcohol or drug use, chronic pain, or psychiatric disorders.

Design outcomes

Primary

MeasureTime frame
total pain;

Secondary

MeasureTime frame
abdomen pain;

Countries

China

Contacts

Public ContactWu Qing
okwq31@163.com+86 15167170568

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026