Coronary heart disease (CHD)
Conditions
Interventions
statin-only group:None
statin + Alirocumab group:None
Alirocumab-only group:None
Sponsors
the Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years, gender unlimited; 2. Diagnosed with Coronary heart disease, defined as coronary atherosclerotic heart disease confirmed by coronary angiography or coronary CT; 3.The fasting LDL-C >= 1.8mmol/L (70mg/dL)
Exclusion criteria
Exclusion criteria: 1.Patients who are treated with lipid-lowering agents other than PCSK9 inhibitors before or while taking statins; 2.Patients who have been treated with multiple types of statins; 3.Patients who are taking other drugs known to affect the effects of statins; 4.Active liver disease or hepatic dysfunction, defined as aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 times; 5.Pregnant or lactating women;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of major adverse cardiovascular events;Total cholesterol;Total glyceride;Low density lipoprotein cholesterol;High density lipoprotein cholesterol;Lipoprotein a;Apolipoprotein B; | — |
Countries
China
Contacts
Public ContactXiang Zhou
Outcome results
None listed