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The Effect of PCSK9 Inhibitors on Retinal Microangiopathy in Patients with Acute Coronary Syndrome

The Effect of PCSK9 Inhibitors on Retinal Microangiopathy in Patients with Acute Coronary Syndrome

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060686
Enrollment
Unknown
Registered
2022-06-07
Start date
2022-06-10
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Interventions

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. At least 18 years of age, regardless of sex; 2. Acute coronary syndrome (including ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, or unstable angina) was diagnosed within 72 hours of onset; 3. Dyslipidemia (LDL-C > 2.6 mmol/ L); 4. Informed consent has been signed.

Exclusion criteria

Exclusion criteria: 1. Cardiogenic shock may require positive inotropic drugs or intraaortic balloon anti-tumor (IABP) support; 2. Uncorrected circulatory congestion or valvular heart disease, which is expected to result in frequent hospitalization or morbidity during follow-up; 3. In the acute episode of heart failure, the patient cannot cooperate with prolonged recumbency; 4. Unable to cooperate with inspection; 5. Poor imaging quality of refractive interstitial opacity; 6. Macular edema or macular anterior membrane and age-related macular degeneration; 7. A history of previous eye surgery; 8. A history of hepatitis B or C; 9.ALT elevation more than 3 times the normal high value or total bilirubin more than 2 times the normal high value; 10. Patients with pacemaker installation; 11. There are other causes of angina pectoris, such as severe aortic valve stenosis or incomplete closure, coronary arteritis caused by rheumatic fever or other reasons, coronary mouth stenosis or occlusion caused by metotoxic aortitis, hypertrophic cardiomyopathy, congenital coronary artery malformation; 12. Other serious cardiovascular and cerebrovascular events, such as stroke or TRANSIENT ischemic attack, occurred in the last 3 months; 13. Patients suffering from diseases such as malignant tumor and multiple organ failure that lead to short life expectancy are expected to live less than 2 months; 14. Suffering from cognitive dysfunction, substance dependence or severe mental illness; 15. Intravenous drug addicts; 16. Women who are pregnant or breast-feeding, or who plan to become pregnant or donate eggs during study participation; 17. Failed to cooperate with follow-up visits; 18. Participate in any other clinical trials; 19. Unable to understand or cooperate with all follow-up visits; 20. Any other factors that may reduce adherence to the test protocol; 21. For any reason, the investigator did not consider it appropriate to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
The area of foveal avascular zone;

Secondary

MeasureTime frame
Retinal vascular density;

Countries

China

Contacts

Public ContactWei Fangfei

The First Affiliated Hospital of Sun Yat-sen University

fangfeimuxiang@163.com+86 13672468116

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026