Predictive value of TREM/NF- ? B pathway mediated intestinal bacterial translocation and immune dysregulation in the occurrence and outcome of major depressive disorder subtypes

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200060624

Enrollment

Unknown

Registered

2022-06-06

Start date

2022-05-30

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Interventions

Case series:None

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-65 (upper limit and lower limit included), no gender limitation; 2.Meet the diagnostic criteria for depressive or atypical depression in the DSM-5; 3.All patients did not take psychiatric drugs in the last 1 month; 4.The patients themselves and their family members or guardians gave informed consent to the study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Other psychiatric disorders that meet the diagnostic criteria of DSM-5: Bipolar Disorder, Schizophrenia, Alcohol and Drug Dependence, Phobias, Acute Stress Disorder and Post-Traumatic Stress Disorder, etc.; 2. Immune and endocrine diseases, brain Vascular disease, tumor, serious heart, liver, kidney and other diseases; 3. Infectious diseases; 4. Women in pregnancy and lactation; 5. Have taken psychiatric drugs within the past month; 6. Have taken antibiotics and probiotics within the past month.

Design outcomes

Primary

Measure	Time frame
TREM;HAMD-17;LBP;	—

Countries

China

Contacts

Public ContactYanyan Wei

Beijing Huilongguan Hospital, Peking University

weidayan66@163.com+86 18674000159

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026