Effect of ropivacaine combined dexmedetomidine epidural infusion on perioperative hemodynamics in patients with varicose veins of the lower extremities

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200060619

Enrollment

Unknown

Registered

2022-06-05

Start date

2022-05-30

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicose veins in the lower extremities

Interventions

0.25ug/kg Dexmedetomidine epidural infusion group:0.25ug/kg Dexmedetomidine epidural infusion

0.5ug/kg Dexmedetomidine epidural infusion group:0.5ug/kg Dexmedetomidine epidural infusion

0.75ug/kg Dexmedetomidine epidural infusion group:0.5ug/kg Dexmedetomidine epidural infusion

0.5 ug/kg dexmedetomidine intravenous infusion group:0.5 ug/kg dexmedetomidine intravenous infusion

Normal saline group:Ropivacaine combined saline epidural infusion

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) ASA grade I or II; (2) Patients who undergo major saphenous varicose vein exfoliation or planing surgery at an elective stage; (3) Age 18-65 years old, gender is not limited; (4) BMI 18.5-23.9kg/m2; (5) No contraindications to spinal canal anesthesia; (6) Sign informed consent.

Exclusion criteria

Exclusion criteria: (1) History of hypertension; (2) Bradycardia (heart rate < 55 beats/ min), hypotension patients; (3) Allergic to dexmedetomidine injection and anesthetics; (4) Contraindicated to spinal canal anesthesia; (5) Long-term use of analgesics, sedatives, depressive drugs and adrenaline receptor antagonists and agonists; (6) Cardiac, hepatic and renal insufficiency; (7) Lower limb movement and hearing impairment

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;heart rate;norepinephrine;Blood oxygen saturation;	—

Secondary

Measure	Time frame
Anesthesia block onset time;Maximum block plane;Anesthesia analgesia time;Sedative score;Pain score;Degree of lower extremity motor block;Recovery time from lower extremity movements;The sedation score reaches its maximum time;Vasoactive drug use;Duration of surgery;Intraoperative blood loss;Amount of infusion;height;weight;Time of administration;Myocardial oxygen consumption;	—

Countries

china

Contacts

Public Contactfangjun wang

wfjlxy006@126.com+86 13458253172

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026