post-intraspinal anesthesia shivering during cesarean section
Conditions
Interventions
Group-esketamine:Epidural inject 5ml of 0.25mg/kg esketamine
control group:Epidural inject 5ml of normal saline
Sponsors
Third People's Hospital of Xuzhou(Xuzhou Cancer Hospital)
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) 18 to 40 years old; 2) ASA Grade ?; 3) Planned cesarean section under spinal anesthesia; 4) Single pregnancy.
Exclusion criteria
Exclusion criteria: 1) Unable to cooperate or refuse to participate; 2) Contraindications to spinal anesthesia, such as infection of puncture site and coagulation dysfunction; 3) Body temperature >=38? or 10×10^9; 4) Unstable mental disorders; 5) muscle or nervous system diseases; 6) Have a history of drug abuse such as alcohol or ketamine; 7) Known to be allergic to esticketamine, bupivacaine and other drugs; 8) Use of drugs or vasodilators that may alter thermoregulation before surgery; 9) Thyroid disease during pregnancy; 10) Have been diagnosed with pregnancy hypertension, congenital heart disease and other circulatory dysfunction; 11) Massive prenatal bleeding; 12) Gestational age 42 weeks; 13) Body mass index > 35 kg/m2; 14) Abnormal liver and renal function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of Shivering; | — |
Secondary
| Measure | Time frame |
|---|---|
| Edinburgh postnatal depression scale,EPDS;Hemodynamic changes;Tympanic membrane temperature;Observer's assessment alert/Sedation,OAA/S;VAS pain score;QoR-40;Apgar score;Bromage score; | — |
Countries
China
Contacts
Public ContactShanshan Zhu
Outcome results
None listed