Sleep disturbance
Conditions
Interventions
sevo+dex:Sevoflurane anesthesia+dexmedetomidine
propofol+dex:Propofol anesthesia+dexmedetomidine
sevo+esk:Sevoflurane anesthesia+esketamine
propofol+esk:Propofol anesthesia+esketamine
sevo:Sevoflurane anesthesia
propofol:Propofol anesthesia
Sponsors
Peking University Cancer Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 35-65 years old; 2. ASA grade I - III; 3. BMI 18.5 -35kg/m2; 4. Cases were diagnosed as breast cancer; 5. Elective radical mastectomy for breast cancer (modified); 6. Informed consent to surgery and this study.
Exclusion criteria
Exclusion criteria: Those who have one of the following circumstances will not be selected as cases: refuse to participate in this study; Preoperative diagnosis was dementia, Alzheimer's disease, delirium and brain metastasis; Unable to communicate or cooperate with relevant examinations due to language disorders or end-stage diseases; Previous diagnosis of central sleep apnea; Have a history of drug or alcohol dependence or have taken sedative / hypnotic drugs within 1 month; History of schizophrenia or mental illness within 3 months or current use of antipsychotics (including antidepressants and anxiolytics); Sick sinus syndrome, severe bradycardia (heart rate < 50 beats/ min), or atrioventricular block of grade II and above without pacemaker; Allergic to DEX or ESK; Patients with elevated intracranial pressure; Poorly controlled or untreated patients with hypertension (arterial hypertension, resting systolic / diastolic blood pressure exceeding 180 / 100mmhg); Patients with hyperthyroidism (hyperthyroidism) without treatment or insufficient treatment; It is expected that endotracheal intubation will be required to enter the ICU after operation; Other researchers think it is not suitable to be selected (specific reasons shall be indicated).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSG outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| RCQS score;Richmond Agitation-Sedation Scale;Subjective sleep score;Actigraph outcomes;VAS scores;nausea and vomiting;Perioperative outcomes;PSQI; | — |
Countries
China
Contacts
Public ContactTan Hongyu
Outcome results
None listed