Acute Pancreatitis and Fluid Resuscitation
Conditions
Interventions
Grouped based on the resuscitation volume:None
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of AP, which requires two of the following three criteria: (1) Typical abdominal pain; (2) Increase in serum amylase or lipase levels higher than three times the upper limit of normality; (3) Signs of AP in imaging (ultrasound\CT\MRI); 2. Patients 18 years or older; 3. Both male and female; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Circulation: hypotension or shock (BP<90/60mmHg); 2. New York Heart Association class II heart failure (slight limitation of physical activity; fatigue, palpitations, or dyspnea with ordinal physical activity) or worse, or ejection fraction <50% in the last echocardiography); 3. Kidney disfunction: basal glomerular filtration rate <60mL/min per 1.73 m2) or need renal replacement therapy; 4. Liver disfunction or Decompensated cirrhosis (Childs class B or C); 5. Respiratory disfunction: respiratory failure(pO2<60mmHg or SpO2<90% or need mechanical ventilation); 6. Pregnant; 7. Clinical signs or symptoms of volume overload or heart failure at recruitment (dyspnea, peripheral edema, ascites); 8. Confirmed chronic pancreatitis or pancreatic malignant tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SIRS and CRP levels of inflammatory indicators after the first 24 hours of fluid supplementation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospitalization stay;Hematocrit, HCT;Blood urea nitrogen, BUN;Creatinine;PaO2/FiO2;Intraperitoneal pressure after fluid replacement; | — |
Countries
Beijing
Contacts
Public ContactZhu Huadong
Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Outcome results
None listed