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Mechanism of NBO (normobaric hyperoxia) treatment on inflammatory injury after intracerebral hemorrhage

Mechanism of NBO (normobaric hyperoxia) treatment on inflammatory injury after intracerebral hemorrhage - NMNBOICH

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200060569
Enrollment
Unknown
Registered
2022-06-05
Start date
2022-05-22
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral hemorrhage

Interventions

ICH+NBO:NBO
ICH:Oxygen

Sponsors

Affiliated Hospital of Jiujiang University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. 18-80 years old, male or female; 2. The included event was spontaneous parenchymal hemorrhage, and no progressive aggravation was observed within 24 hours of onset, including supratentorial and subatentorial; 3. Agree to participate in the clinical trial and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Simple ventricular hemorrhage, subarachnoid hemorrhage, and brainstem hemorrhage; 2. Massive intracerebral hemorrhage and cerebral hernia requiring craniotomy; 3. The patient has uncontrollable hypertension (systolic blood pressure is greater than 180mmhg or diastolic blood pressure is greater than 110mmhg after drug treatment; 4. Known history of severe chronic obstructive pulmonary disease or asthma (forced expiratory vital capacity less than 1.0L or oxygen dependent); 5. New York Heart Association grade III heart failure; 6. Coma (GCS = 2; 8. Participating in other clinical research.

Design outcomes

Primary

MeasureTime frame
National Institute of Health stroke scale;Modified Rankin Scale;IL-18;Caspase-1;

Secondary

MeasureTime frame
Randomized 14-day CTP brain perfusion improvement;

Countries

China

Contacts

Public ContactBao Bing

Affiliated Hospital of Jiujiang University

272908465@qq.com+86 13879201367

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026