Osteoarthritis
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Primary and unilateral end-stage primary or secondary knee osteoarthritis, traumatic arthritis, and patients who need TKA surgery; 2. Age 18 to 80 years old; 3. Patients who voluntarily participated in clinical trials and signed the informed consent form with good compliance.
Exclusion criteria
Exclusion criteria: 1. Preoperative CRP>10mg/L, IL-6>15pg/ml; 2. Patients with uncontrolled systemic infections such as pulmonary infection and urinary tract infection before surgery; 3. Knee flexion deformity >15 degree, varus deformity >10 degree, valgus deformity >15 degree, with obvious bone defect (AORI > type I); 4. ASA classification > grade III; 5. Use of drugs that affect the function of the coagulation system (such as aspirin, clopidogrel, ticlopidine, dipyridamole, ginkgo biloba preparations, heparin, warfarin, citrate, blood coagulation) 1 week before surgery Enzyme, Vk, antifibrinolytic, hemostatic sensitivity, Vc, etc.); 6. Those with abnormal coagulation function or thromboelastographic before surgery; 7. Clearly allergic to TXA or contraindicated; 8. Patients with old deep vein thrombosis, severe varicose veins, and arterial occlusion in the lower limbs on the affected side; 9. Patients with a history of myocardial infarction, angina pectoris, cerebral infarction and epilepsy in the past 6 months; 10. Those with hemoglobin 35kg/m2; 12. Patients who are considered unsuitable by the investigator to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin;Hematocrit;ESR;CRP;IL-6;Perioperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| APTT;PT;INR;d-dimer;FDP;Range Of Motion, ROM;Hospital for special surgery score system;Limb circumference; | — |
Countries
China
Contacts
Public ContactHuang Qiang
West China Hospital of Sichuan University
Outcome results
None listed