Effects of optimizing hemodynamic parameters on inhibiting perioperative stress response and postoperative myocardial injury in non-cardiac surgery patients.

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200060561

Enrollment

Unknown

Registered

2022-06-04

Start date

2022-05-30

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial injury

Interventions

The control group:Oral placebo the night before surgery.BP and HR fluctuation <= 20% of the base value

The experimental group:Estazolam tablets were taken orally 1mg on the night and morning before surgery, respectively.The ratio of MAP to HR (MAP/HR) is greater than 1. The MAP above 65 mmHg

Eligibility

Sex/Gender

All

Age

45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. 70 patients under general anesthesia for elective non-cardiac surgery were selected; 2. ASA grade I or II, age over 45 years, operation time over 1 hours; 3. Patients with at least primary school education.

Exclusion criteria

Exclusion criteria: 1. Complicated with severe respiratory diseases: asthma, pulmonary bullae, chronic obstructive pulmonary disease, etc.; 2. Complicated with serious cardiovascular diseases: congenital heart disease, coronary heart disease, moderate to severe hypertension, etc.; 3. Serious complications occurred during the operation, such as massive bleeding and anaphylactic shock.

Design outcomes

Primary

Measure	Time frame
Troponin I;Blood pressure;Heart rate;Blood glucose;	—

Countries

China

Contacts

Public ContactLin Xue

The Second Affiliated Hospital of Harbin Medical University

LX84635616@163.com+86 13796674236

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026