Helicobacter pylori
Conditions
Interventions
Experimental group:Amoxicillin + Vonorosen
Control group:Individualized therapy
Sponsors
Army Medical Center, The Amy Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years, male or female; 2. At least once failure of Hp eradication; 3. Gastroscopy diagnosis of chronic gastritis, with or without gastric ulcer or duodenal ulcer healed; 4. The rapid urease test, the urea breath test, and anti-H.pylori culture was positive; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. PPI, antibiotics, H2 receptor antagonists, bismuth agents, probiotics, potassium competitive acid blockers, and other drugs were used within four weeks before treatment; 2. Patients with allergies to the drugs used in this study; 3. Patients with previous gastric and esophageal surgery; 4. Serious concomitant diseases: heart, lung, liver, kidney, metabolic disease, mental illness, or malignant tumors; 5. Pregnant or lactating women, patients who had a birth plan during the study period; 6. Previous undergone dual therapy to cure Hp; 7. Culture negative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient compliance;Symptoms of digestive tract were assessed before and after treatment;Antibiotic resistance of HP;HP capacity;CYP2C19 gene polymorphism;Effects of patients before and after treatment on intestinal microecology;Treatment cost;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactChun-Hui Lan
Army Medical Center
Outcome results
None listed