ischemic stroke
Conditions
Interventions
N/A(Phase 1):Mirror therapy
MT non-responders Group A(Phase 2):rTMS combined with MT
MT non-responders Group B(Phase 2):Sham rTMS combined with MT
MT responders Group A(Phase 2):rTMS combined with MT
MT responders Group B(Phase 2):Sham rTMS combined with MT
Sponsors
Fifth Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the stroke diagnostic criteria set by the fourth National Academic Conference on Cerebrovascular Diseases; 2. Confirmed as ischemic stroke by CT or MRI, with a course of disease over 6 months; 3. Hemiplegia after stroke, with Brunnstrom stage of 1–3; 4. Montreal Cognitive Assessment (MoCA) score >=21; 5. 50-75 years old; 6. Right-handedness; 7. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous medical history of upper limb fracture, upper limb deformity, etc; 2. Unstable condition or change in patients condition occurred during the experiment, affecting the experimental results; 3. Cannot complete the experiment because of severe heart, lung, liver and kidney and other important organ diseases; 4. Severe cognitive dysfunction or aphasia; 5. Has severe mental disorder; 6. Taking medication that lower the seizure threshold; 7. Patients with contraindications to rTMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenated hemoglobin concentration in the brain region of interest;Motor evoked potential;Surface electromyography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Fugl-Meyer assessment-upper limb;Action Research Arm test; | — |
Countries
China
Contacts
Public ContactQiu Yaxian
Fifth Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed