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Effect of autologous platelet separation on coagulation function and prognosis in patients undergoing Stanford type A dissection total arch replacement

Effect of autologous platelet separation on coagulation function and prognosis in patients undergoing Stanford type A dissection total arch replacement

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200060536
Enrollment
Unknown
Registered
2022-06-04
Start date
2022-06-06
Completion date
Unknown
Last updated
2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stanford type A aortic dissection

Interventions

None listed

Sponsors

Guangdong Provincial Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients proposed to undergo Stanford type A dissection total arch replacement; 2. Platelet separation was performed before the operation; 3. Unlimited gender; 4. Age 23-64; 5. The American Society of Anesthesiologists (ASA) is classified as grade I - IV; 6. All patients have been diagnosed as Stanford type A aortic dissection by preoperative aortography.

Exclusion criteria

Exclusion criteria: 1. It is difficult to maintain stable hemodynamics during autologous platelet separation; 2. Complicated with coagulation dysfunction (use of anticoagulant drugs within 7 days, etc.); 3. Complicated with hematological diseases or using anticoagulants or antiplatelet drugs within 1 week before the operation; 4. The onset of dissection was more than 2 weeks; 5. Preoperative platelet count was less than 100*10^9 /L; 6. Hemoglobin count is less than 100g/L; 7. HCT<35%; 8. There are other situations that cannot complete this study.

Design outcomes

Primary

MeasureTime frame
Thromboelastogram (TEG) coagulation function index;

Secondary

MeasureTime frame
Renal function;Cerebral oxygen saturation;Cognitive function evaluation;

Countries

China

Contacts

Public ContactGaofeng Zhao

Guangdong Provincial Hospital of Traditional Chinese Medicine

zhaogaofeng_97@163.com+86 15920387021

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026