Obsessive compulsive disorder
Conditions
Interventions
Obsessive-compulsive disorder group vs. healthy control group:None
Healthy control group:None
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Patients with obsessive-compulsive disorder (OCD group): (1) Patients with obsessive-compulsive disorder who met the diagnostic criteria in the American Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) after a meeting with two senior psychiatrists; (2) The Y-BOCS score was more than 16 as assessed by experienced doctors; (3) Age 18-55, Han nationality, right-handed. 2. Healthy control group (HC group): (1) No mental disorders conforming to DSM-V axis I after SID interview screening. No mental disorder or inherited neurological disease in first-degree relatives; (2) 18-55 years old, Han nationality, right-handed; (3) The subjects voluntarily participated in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Obsessive-compulsive Disorder group (OCD group): (1) Combined with other mental disorders or drug or alcohol dependence; (2) Suffering from serious physical diseases such as heart, liver, and kidney insufficiency; (3) Pregnant or lactating women; (4) Have a history of major head trauma (loss of consciousness, time & GT; 5min), neurological diseases; (5) There are contraindications to MRI (with metal implants, claustrophobia, etc.) and eeg (head trauma and non-healing incision after surgery, etc.); (6) Subjects who are participating in other clinical trials. 2. Healthy control group (HC group): (1) History of alcohol and/or drug abuse and dependence (except nicotine dependence); (2) Have a history of head trauma (loss of consciousness, time >5 minutes), neurological diseases; (3) Suffering from serious physical diseases such as heart, liver and kidney insufficiency and poorly controlled diabetes; (4) Pregnant or lactation women; (5) There are contraindications to MRI (with metal implants, claustrophobia, etc.) and eeg (head trauma and non-healing incision after surgery, etc.); (6) Subjects who are participating in other clinical trials that may affect the results of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral magnetic resonance index;Electroencephalogram index;clinical symptoms;Cognitive evaluation; | — |
Countries
China
Contacts
Public ContactHaisan Zhang
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed