Cardiac surgery under cardiopulmonary bypass
Conditions
Interventions
Treatment group:Ramazolam
Control group:Propofol
Sponsors
First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-64 years old, undergoing elective extracorporeal circulation coronary artery bypass grafting, valve replacement or repair surgery, coronary artery bypass graft combined with valve replacement or repair surgery; 2. ASA grading II-IV; 3. NYHA grading II-III; 4. Sign the subject's informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are known contraindications to the use of remazolam and propofol; 2. Preoperative ejection fraction < 35%; 3. Basal mean arterial pressure (MAP) before anesthesia < 65mmHg, basal heart rate < 50 beats/min; 4. Have a history of neuropsychiatric psychiatrics in the past or have recently taken drugs that affect the central nervous system; 5. Those who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP-time integral; | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of drugs on hemodynamics;To evaluate the correlative indexes of organ injury;To evaluate the effect of drugs on brain waves; | — |
Countries
China
Contacts
Public ContactHou Lihong
First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed