cerebral small vessel disease
Conditions
Interventions
Case series:None
Sponsors
Shenzhen Qianhai Shekou Free Trade Zone Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 45-85 years; 2. Can receive head MRI examination; 3. Obtain the informed consent of the subjects themselves or their families, and sign the written informed consent.
Exclusion criteria
Exclusion criteria: 1. In the stage of acute cerebrovascular disease, including subarachnoid hemorrhage, acute hemorrhagic stroke, acute ischemic stroke (except lacunae); 2. Previous or current history of major head trauma or any intracranial surgery; 3. There are small cerebral vascular lesions caused by immunity, poisoning, metabolism and infection; 4. The presence of extrapyramidal symptoms or mental illness affecting the assessment of cognitive function; 5. Intracranial space-occupying lesions; 6. Unable to communicate properly due to language barriers, audio-visual barriers, etc.; 7. There are trauma, severe acute infectious diseases, and severe liver and kidney insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers of vascular endothelial dysfunction;Cerebral small vessel disease imaging markers;Neuropsychological assessment;Biomarkers of blood-brain barrier injury;Proteomics;Metabonomics;Epigenetics;Life and behavioral risk factors;Social factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| Affective disorder;Defecation disorder;Gait disorder;Disability;All cause death; | — |
Countries
China
Contacts
Public ContactLu Ciyong
Sun Yat-Sen University
Outcome results
None listed