Efficacy of midazolam oral solution in reducing postoperative agitation caused by sevoflurane anesthesia in young children

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200060494

Enrollment

Unknown

Registered

2022-06-03

Start date

2022-05-23

Completion date

Unknown

Last updated

2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group A:Oral midazolam oral solution 0.5 mg/kg 30 minutes before surgery, and intranasal saline instillation after anesthesia

Group B:Oral common syrup 30 minutes before operation, and intranasal dexmedetomidine 1 µg/kg after anesthesia

Group C:Oral syrup was administered orally 30 minutes before surgery, and saline nasal drops were administered through the nose after anesthesia

Eligibility

Sex/Gender

All

Age

0.5 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. Young children (aged >=6 months, 4METs; 3. Written informed consent shall be signed by the authorized researcher and guardian of the child.

Exclusion criteria

Exclusion criteria: 1. Oral administration of other sedative drugs before surgery; 2. Children allergic to midazolam or other components of this product; 3. Preoperative difficult airway assessment, Mallampati grade >=?; 4. Children with acute angle-closure glaucoma or children with open-angle glaucoma without effective treatment.

Design outcomes

Primary

Measure	Time frame
sedative effectiveness;sobriety;agitation occurs;degree of agitation;	—

Secondary

Measure	Time frame
recovery time;	—

Countries

China

Contacts

Public ContactWang Lin

Rizhao Central Hospital

120385626@qq.com+86 15006331517

Outcome results