Postoperative Delirium
Conditions
Interventions
Control group:None
Sponsors
Shenzhen Longgang District Third People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients voluntarily agreed to participate in this study and signed informed consent; 2. The patient aged over 50 years, with smooth language communication and no obvious hearing and visual impairment; 3. The patient has no history of mental illness (depression, schizophrenia), dementia, substance abuse or alcoholism; 4. Elective or limited-period general anesthesia surgery is proposed, and the surgical type is limited to non-cardiac surgery major open surgery (Major surgery is defined as tertiary or tertiary surgery performed under general anesthesia and expected operation time is more than 2 hours).
Exclusion criteria
Exclusion criteria: 1. The patient also participated in other clinical studies; 2. Long-term severe sleep disorder or insomnia; 3. Preoperative epilepsy, Parkinson's disease, myasthenia gravis; 4. Craniocerebral injury or neurosurgery; Having had neck trauma or surgery; 5. Preoperative LVEF<30%, or patients with sick sinus syndrome, severe sinus bradycardia (heart rate <50 beats/min), atrioventricular block above degree II and no pacemaker implantation; 6. Severe abnormal liver function (Child-Pugh grade C); 7. Severe renal dysfunction (preoperative dialysis); 8. Patients with ASA Grade IV or expected survival <=24 hours; 9. Cases considered unsuitable for inclusion by other researchers.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Delirium duration;Severity of delirium; | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery;Postoperative sleep quality;Changes of plasma BDNF concentration in perioperative patients; | — |
Countries
China
Contacts
Public ContactLi Yongwang
Shenzhen Longgang District Third People's Hospital
Outcome results
None listed