adolescent depression
Conditions
Interventions
drug-naive iTBS+cTBS group:Intermittent ? Burst Stimulation (iTBS) + Persistent ? Burst Stimulation (cTBS)
drug-naive iTBS group:iTBS
drug-naive sham group:Pseudo-stimulus
treatment-resistant depression iTBS+cTBS group:iTBS+cTBS
treatment-resistant depression iTBS group:iTBS
treatment-resistant depression sham group:Pseudo-stimulus
Sponsors
Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 12-18 years; 2. Diagnosed with major depressive disorder by screening SCID-5 and DSM-5; 3. HAMD-17 score >= 17; 4. Drug-naive cohort: meeting psychopharmacological drug-naive; treatment-resistant depression: meeting the definition of treatment-resistant depression: at least one category of antidepressants was used in sufficient amounts in treatment course and they reported a poor therapeutic effect; 5. Both the subjects and their guardians sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or claustrophobic; 2. History of organic brain disease, brain trauma or surgery; 3. Patients with major physical diseases such as heart, liver and kidney cannot tolerate this study; 4. Received MECT treatment within three months; 5. Previous history of seizures; 6. Contraindications for MRI examination; 7. There are contraindications to TMS therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale 17 item version (HDRS-17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic Resonance Imaging;Montgomery-Asberg Depression Rating Scale (MADRS);Hamilton Anxiety Scale;Columbia Suicide Severity Rating Scale, C-SSRS;Revised Non-suicidal NSSI Questionnaire Based on Ottawa NSSI Questionnaire;The Beck Hopelessness Scale;The 14-item McIntyre and Rosenblat Rapid Response Scale;McGill Pain Questionnaire Short-Form;Cognitive function;Snaith-Hamilton Pleasure Scale;Electroencephalogram;Global Assessment Function, GAF;rTMS Adverse Event Rating Scale; | — |
Countries
China
Contacts
Public ContactZhou Yanling
Outcome results
None listed