Cerebral Palsy
Conditions
Interventions
Experimental group:Umbilical cord blood mononuclear cells were transfused
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Children with cerebral palsy (spastic cerebral palsy caused by periventricular white matter injury, perinatal stroke or neonatal brain injury caused by intraventricular hemorrhage). 2. Meet Gross Motor Function Classification Score level(GMFCS) II-V. 3. Aged 2 to 7 years, weight 11-27kg, no gender limit. 4. Agreed to undergo post-rehabilitation treatment in the Second Hospital of Hebei Medical University.
Exclusion criteria
Exclusion criteria: 1. Existing history: intractable epilepsy, traumatic brain injury, hereditary disease, severe heart, lung, liver, and renal dysfunction (serum creatinine > 1.5 mg/dl, SGPT > 150 U/L at screening). History of syphilis, HIV and hepatitis; HIV+, immunosuppression (WBC 37.5?), vomiting, diarrhea, wheezing or wet rales. 4. Degenerative nervous system diseases (e.g., Batten disease, leukodystrophy, metabolic disorders, mitochondrial disorders, neurotransmitter disorders). 5. Microcephaly, macrocephaly, cortical malformation, genetic disorders of dysplastic encephalopathy caused by infection or metabolic diseases. 6. Previous history of stem cell therapy. 7. Patients who cannot cooperate with follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of Daily Living (ADL) Score;Modified Ashworth Spasm Rating Scale;Pediatric Cerebral Palsy Gross Motor Assessment Scale Score;Comprehensive Functional Assessment Table of Cerebral Palsy;Language and Social Skills Tests; | — |
Countries
China
Contacts
Public ContactWang Xiuxia
The Second Hospital of Hebei Medical University
Outcome results
None listed