schizophrenia (SCZ)
Conditions
Interventions
schizophrenia group:Risperidone
healthy control group:None
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. The Chinese version of SCID-I/P, a DSM-IV examination tool, was adopted for systematic psychiatric examination of patients, which met the diagnostic criteria of SCZ, and the score of positive and negative symptom scale (PANSS) was > 60; 2. First dose and no antipsychotic medication; 3. Aged between 18 and 45 years; 4. BMI not exceeding 24kg/m^2; 5. Informed consent of patients and their families.
Exclusion criteria
Exclusion criteria: 1. Suffering from physical diseases of the heart, liver, gallbladder, kidney, endocrine and immune system diseases, malnutrition, gastrointestinal diseases and other mental disorders; 2. Have a history of allergy and hormone therapy, and have received immune preparations or antibiotics; 3. Vaccination in the near future; 4. Pregnant or lactating patients; 5. Left-handed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Symptom Scale (PANSS) Score;gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function;metabolimics;brain magnetic resonance imaging;inflammatory markers; | — |
Countries
China
Contacts
Public ContactSong Xueqin
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed